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Chemistry

3/11/2017

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How does it kill you?
Depolarize cell membranes.
Batrachotoxin.

Tim MacKenzie

Stanford University

Synthetic Batrachotoxin Derivatives as Molecular Probes of Voltage-Gated Sodium Channel Function
Through de novo chemical synthesis, I prepare structural analogues of batrachotoxin, a steroidal neurotoxin found in Colombian poison dart frogs. After synthesis of the derivatives, I perform patch clamp electrophysiology using voltage-gated sodium channels to determine the effects of the toxin. By seeing how structural perturbations impact toxin effects, we can begin to build a molecular understanding of the workings of the protein involved in initiating electrical signalling in the body.

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Chemistry

3/3/2017

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Water chemistry 
in the very first step of
photosynthesis.

Tom Kuntzleman
University of Michigan

Redox Chemistry of the Calcium-Manganese Cluster of Photosystem II as Probed by Chemical Reducing Agents
Photosystem II (PSII) is an enzyme that catalyzes the splitting of water into protons, electrons and oxygen gas in the very first step of photosynthesis. I observed the reaction of PSII with a variety of different chemicals to learn about the chemistry of PSII.

​
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Materials Chemistry

9/27/2011

 
​Growing new tissue
Cells need a scaffold for growth
PHEMA can be used

​
Stefan Paterson
University of Western Australia

​Thesis Title:  “The synthesis of PHEMA-based materials for tissue engineering applications”.
My thesis came under the broad research area of tissue engineering, but more specifically, involved the used of four very different areas of chemistry to synthesize enzymatically degradable macroporous polymeric materials. These materials were degraded in vitro using enzymes, with the degradation profiles of the materials being suitable for tissue engineering applications.

Medicinal Chemistry

5/19/2011

 
​Bad carcinogen
Cannot kill the best enzyme
for its own demise.

​
Laura Shireman
University of Washington

​My Ph.D. in medicinal chemistry focused on the mechanistic enzymology of glutathione transferases, a class of drug-metabolizing enzyme. One chapter focused on a gnarly carcinogen, 4-hydroxynonenal, that mucks up the works for all kinds of proteins in the body, including enzymes that metabolize it. However, the glutathione transferase that metabolizes and thereby detoxifies 4-hydroxynonenal with the highest catalytic efficiency, GST A4-4, also resists its adduction.

Chemistry

11/22/2009

 
​Chiral Induction
strokes my mind with Organic
(chemist) Seduction


השראה כיראלית
מלטפת ברוך את
תת ההכרה
​
Anat Milo
Weizmann Institute of Science, Israel

​My research is focused on developing solid-state organic-inorganic hybrid materials for the induction of chirality upon various organic transformations.

Chemistry

9/5/2009

 
​Ras causes cancer
Stop farnesyl transferase
That makes it better

​
Scott Lefler
Arizona State University

​Farnesyl transferase inhibitors and inactivators: potential anti-cancer chemotherapeutic agents
A quarter of all cancer is caused by a mutation in the Ras protein. For Ras proteins to be active, they must be modified by the enzyme farnesyl transferase. Inhibiting this enzyme has the potential to cure many different types of cancer.

Chemistry

9/5/2009

 
​Dust can form from air.
Make this happen in steel can
and watch other worlds.

​
Mate Adamkovics
University of California, Berkely

​Dissertation Title: “Hydrocarbon Photochemistry in Planetary Atmospheres: Laboratory and Observational Investigations of Organic Aerosols”

Chemistry

9/3/2009

 
​DNA can break
via a mechanism
not well understood

​
Kirstin Hendrickson
Arizona State University

​Dissertation Title: Proton Transfer in One-Electron Oxidized Guanine-Cytosine and Adenine-Thymine Base Pairs
My dissertation research was an attempt to determine the specific mechanism (what happens on a molecular level) of the chemical reaction through which our genetic material, DNA, can break if subjected to chemical stress, such as through exposure to UV light or toxins.

Chemistry

7/20/2009

 
N  H  2  C   l
Heat vapor then quickly cool.
blue free radicals.

​
Jim Klent
Catholic University of America
Working with F.O. Rice we ran substances such as chloramine at very low pressures through a quartz furnace at 1200K.  The heated vapor would then hit a liquid nitrogen cooled surface.  Products were often colorful substances stable only at very low temperatures.

Chemistry

3/1/2009

 
collecting data:
a task Sisyphean, with
mass spec for boulder

​

Eli Rosen
University of North Carolina at Chapel Hill

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Dissertation Haiku in the News!

​​​           Doctoral Dissertations in Haiku
“One of my old professors liked to say that a poem isn’t any good unless you can explain it to a three-year-old. I never would have thought one could apply that same standard to a doctoral dissertation, but then I came across a brilliant little website called Dissertation Haiku.” 
Full Article in Huffington Post 
John Lundberg Writer, Poetry Teacher
09/30/2009 05:12 am ET | Updated Nov 17, 2011
        Dissertations are Long and Boring​
"This indisputable fact is the impetus behind the genius blog Dissertation Haiku, which explains itself thus: Dissertations are long and boring. By contrast everyone likes haiku. So why not write your dissertation as a haiku?
Full Article in The New Yorker 

Macy Halford  Contributor
09/23/2009

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