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How does it kill you?
Depolarize cell membranes. Batrachotoxin. Tim MacKenzie Stanford University Synthetic Batrachotoxin Derivatives as Molecular Probes of Voltage-Gated Sodium Channel Function Through de novo chemical synthesis, I prepare structural analogues of batrachotoxin, a steroidal neurotoxin found in Colombian poison dart frogs. After synthesis of the derivatives, I perform patch clamp electrophysiology using voltage-gated sodium channels to determine the effects of the toxin. By seeing how structural perturbations impact toxin effects, we can begin to build a molecular understanding of the workings of the protein involved in initiating electrical signalling in the body.
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Water chemistry
in the very first step of photosynthesis. Tom Kuntzleman University of Michigan Redox Chemistry of the Calcium-Manganese Cluster of Photosystem II as Probed by Chemical Reducing Agents Photosystem II (PSII) is an enzyme that catalyzes the splitting of water into protons, electrons and oxygen gas in the very first step of photosynthesis. I observed the reaction of PSII with a variety of different chemicals to learn about the chemistry of PSII. Growing new tissue
Cells need a scaffold for growth PHEMA can be used Stefan Paterson University of Western Australia Thesis Title: “The synthesis of PHEMA-based materials for tissue engineering applications”. My thesis came under the broad research area of tissue engineering, but more specifically, involved the used of four very different areas of chemistry to synthesize enzymatically degradable macroporous polymeric materials. These materials were degraded in vitro using enzymes, with the degradation profiles of the materials being suitable for tissue engineering applications. Bad carcinogen
Cannot kill the best enzyme for its own demise. Laura Shireman University of Washington My Ph.D. in medicinal chemistry focused on the mechanistic enzymology of glutathione transferases, a class of drug-metabolizing enzyme. One chapter focused on a gnarly carcinogen, 4-hydroxynonenal, that mucks up the works for all kinds of proteins in the body, including enzymes that metabolize it. However, the glutathione transferase that metabolizes and thereby detoxifies 4-hydroxynonenal with the highest catalytic efficiency, GST A4-4, also resists its adduction. Chiral Induction
strokes my mind with Organic (chemist) Seduction השראה כיראלית מלטפת ברוך את תת ההכרה Anat Milo Weizmann Institute of Science, Israel My research is focused on developing solid-state organic-inorganic hybrid materials for the induction of chirality upon various organic transformations. Ras causes cancer
Stop farnesyl transferase That makes it better Scott Lefler Arizona State University Farnesyl transferase inhibitors and inactivators: potential anti-cancer chemotherapeutic agents A quarter of all cancer is caused by a mutation in the Ras protein. For Ras proteins to be active, they must be modified by the enzyme farnesyl transferase. Inhibiting this enzyme has the potential to cure many different types of cancer. Dust can form from air.
Make this happen in steel can and watch other worlds. Mate Adamkovics University of California, Berkely Dissertation Title: “Hydrocarbon Photochemistry in Planetary Atmospheres: Laboratory and Observational Investigations of Organic Aerosols” DNA can break
via a mechanism not well understood Kirstin Hendrickson Arizona State University Dissertation Title: Proton Transfer in One-Electron Oxidized Guanine-Cytosine and Adenine-Thymine Base Pairs My dissertation research was an attempt to determine the specific mechanism (what happens on a molecular level) of the chemical reaction through which our genetic material, DNA, can break if subjected to chemical stress, such as through exposure to UV light or toxins. N H 2 C l
Heat vapor then quickly cool. blue free radicals. Jim Klent Catholic University of America Working with F.O. Rice we ran substances such as chloramine at very low pressures through a quartz furnace at 1200K. The heated vapor would then hit a liquid nitrogen cooled surface. Products were often colorful substances stable only at very low temperatures. collecting data:
a task Sisyphean, with mass spec for boulder Eli Rosen University of North Carolina at Chapel Hill |
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Graduate Student Walden University Public Policy and Public Administration Archives
December 2016
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