How does it kill you?
Depolarize cell membranes.
Synthetic Batrachotoxin Derivatives as Molecular Probes of Voltage-Gated Sodium Channel Function
Through de novo chemical synthesis, I prepare structural analogues of batrachotoxin, a steroidal neurotoxin found in Colombian poison dart frogs. After synthesis of the derivatives, I perform patch clamp electrophysiology using voltage-gated sodium channels to determine the effects of the toxin. By seeing how structural perturbations impact toxin effects, we can begin to build a molecular understanding of the workings of the protein involved in initiating electrical signalling in the body.
in the very first step of
University of Michigan
Redox Chemistry of the Calcium-Manganese Cluster of Photosystem II as Probed by Chemical Reducing Agents
Photosystem II (PSII) is an enzyme that catalyzes the splitting of water into protons, electrons and oxygen gas in the very first step of photosynthesis. I observed the reaction of PSII with a variety of different chemicals to learn about the chemistry of PSII.
Growing new tissue
Cells need a scaffold for growth
PHEMA can be used
University of Western Australia
Thesis Title: “The synthesis of PHEMA-based materials for tissue engineering applications”.
My thesis came under the broad research area of tissue engineering, but more specifically, involved the used of four very different areas of chemistry to synthesize enzymatically degradable macroporous polymeric materials. These materials were degraded in vitro using enzymes, with the degradation profiles of the materials being suitable for tissue engineering applications.
Cannot kill the best enzyme
for its own demise.
University of Washington
My Ph.D. in medicinal chemistry focused on the mechanistic enzymology of glutathione transferases, a class of drug-metabolizing enzyme. One chapter focused on a gnarly carcinogen, 4-hydroxynonenal, that mucks up the works for all kinds of proteins in the body, including enzymes that metabolize it. However, the glutathione transferase that metabolizes and thereby detoxifies 4-hydroxynonenal with the highest catalytic efficiency, GST A4-4, also resists its adduction.
strokes my mind with Organic
מלטפת ברוך את
Weizmann Institute of Science, Israel
My research is focused on developing solid-state organic-inorganic hybrid materials for the induction of chirality upon various organic transformations.
Ras causes cancer
Stop farnesyl transferase
That makes it better
Arizona State University
Farnesyl transferase inhibitors and inactivators: potential anti-cancer chemotherapeutic agents
A quarter of all cancer is caused by a mutation in the Ras protein. For Ras proteins to be active, they must be modified by the enzyme farnesyl transferase. Inhibiting this enzyme has the potential to cure many different types of cancer.
Dust can form from air.
Make this happen in steel can
and watch other worlds.
University of California, Berkely
Dissertation Title: “Hydrocarbon Photochemistry in Planetary Atmospheres: Laboratory and Observational Investigations of Organic Aerosols”
DNA can break
via a mechanism
not well understood
Arizona State University
Dissertation Title: Proton Transfer in One-Electron Oxidized Guanine-Cytosine and Adenine-Thymine Base Pairs
My dissertation research was an attempt to determine the specific mechanism (what happens on a molecular level) of the chemical reaction through which our genetic material, DNA, can break if subjected to chemical stress, such as through exposure to UV light or toxins.
N H 2 C l
Heat vapor then quickly cool.
blue free radicals.
Catholic University of America
Working with F.O. Rice we ran substances such as chloramine at very low pressures through a quartz furnace at 1200K. The heated vapor would then hit a liquid nitrogen cooled surface. Products were often colorful substances stable only at very low temperatures.
a task Sisyphean, with
mass spec for boulder
University of North Carolina at Chapel Hill
Public Policy and
© Copyright 2016
All Rights Reserved